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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALDH18A1
All Species:
35.45
Human Site:
T458
Identified Species:
55.71
UniProt:
P54886
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54886
NP_001017423.1
795
87302
T458
V
G
R
V
L
R
R
T
R
I
A
K
N
L
E
Chimpanzee
Pan troglodytes
XP_001155890
796
87730
T459
V
G
R
V
L
R
R
T
R
I
A
K
N
L
E
Rhesus Macaque
Macaca mulatta
XP_001099359
795
87154
T458
V
G
R
V
L
R
R
T
R
I
A
K
N
L
E
Dog
Lupus familis
XP_534976
795
87233
T458
V
G
R
V
L
R
R
T
R
I
A
K
N
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z110
795
87278
T458
V
G
R
V
L
R
R
T
R
I
A
K
N
L
E
Rat
Rattus norvegicus
NP_001101994
795
87311
T458
V
G
R
V
L
R
R
T
R
I
A
K
N
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508419
607
66410
P300
E
S
R
P
D
C
L
P
Q
V
A
A
L
A
I
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086040
815
89190
T478
V
G
R
V
L
R
R
T
R
I
A
K
D
L
E
Zebra Danio
Brachydanio rerio
NP_001077015
782
85358
T440
V
G
R
V
L
R
R
T
R
V
A
N
N
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649375
776
84074
T444
V
G
R
V
L
R
R
T
R
L
A
D
Q
L
E
Honey Bee
Apis mellifera
XP_396399
732
79216
V418
V
P
I
G
V
L
L
V
I
F
E
S
R
P
D
Nematode Worm
Caenorhab. elegans
P54889
800
86509
V450
V
G
R
V
L
K
K
V
K
I
S
E
G
L
F
Sea Urchin
Strong. purpuratus
XP_781524
752
81324
R418
L
S
D
G
M
L
L
R
Q
V
T
V
P
I
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54888
726
78853
L419
F
E
S
R
P
D
A
L
V
Q
I
A
S
L
A
Baker's Yeast
Sacchar. cerevisiae
P54885
456
49722
K149
A
A
I
L
K
G
G
K
E
S
V
N
T
F
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.9
97.4
97.1
N.A.
95.3
95.2
N.A.
71.6
N.A.
84.4
82.1
N.A.
55.9
54.7
52.5
56.4
Protein Similarity:
100
94.9
98.2
98.6
N.A.
97.7
97.4
N.A.
74.9
N.A.
90.8
91.5
N.A.
70.8
69.5
69.5
73.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
13.3
N.A.
93.3
86.6
N.A.
80
6.6
46.6
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
26.6
N.A.
100
93.3
N.A.
86.6
20
80
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
44.6
22.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.1
38.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
0
0
7
0
0
0
67
14
0
7
7
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
7
7
0
0
0
0
0
7
7
0
7
% D
% Glu:
7
7
0
0
0
0
0
0
7
0
7
7
0
0
60
% E
% Phe:
7
0
0
0
0
0
0
0
0
7
0
0
0
7
7
% F
% Gly:
0
67
0
14
0
7
7
0
0
0
0
0
7
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
14
0
0
0
0
0
7
54
7
0
0
7
7
% I
% Lys:
0
0
0
0
7
7
7
7
7
0
0
47
0
0
0
% K
% Leu:
7
0
0
7
67
14
20
7
0
7
0
0
7
74
0
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
14
47
0
0
% N
% Pro:
0
7
0
7
7
0
0
7
0
0
0
0
7
7
0
% P
% Gln:
0
0
0
0
0
0
0
0
14
7
0
0
7
0
0
% Q
% Arg:
0
0
74
7
0
60
60
7
60
0
0
0
7
0
7
% R
% Ser:
0
14
7
0
0
0
0
0
0
7
7
7
7
0
0
% S
% Thr:
0
0
0
0
0
0
0
60
0
0
7
0
7
0
0
% T
% Val:
74
0
0
67
7
0
0
14
7
20
7
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _